Adapting HPLC to the Capillary Scale: Insights from Academia and Industry (Apr 2026)

Adapting high-performance liquid chromatography (HPLC) methods to the capillary scale opens new possibilities for pharmaceutical analysis and sustainability. This paper, featuring a collaboration with the University of Pavia and Axcend, examines real-world method conversions that preserve performance while minimizing waste. Case studies include detection of a polar impurity in pediatric ibuprofen mini-tablets using a micro-HPLC-UV method, and a USP <621> guided adaptation for hydrochlorothiazide demonstrating over 99% solvent reduction. Practical guidelines, expected trade-offs, and data from both academic and regulated environments will offer a roadmap to adapting validated pharmaceutical monographs to the capillary scale without the need for revalidation.

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Understand how to translate pharmaceutical monographs to the capillary scale without revalidation.
Identify expected performance gains and trade-offs at low-flow rates.
Explore real-world data from academic and regulated environments.

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